Blood Coagulation Tubes are an essential tool in obtaining blood for many types of laboratory tests. From hematology, to genetics, to molecular biology, scientists use blood collection tubes on a daily basis. There are various types of blood coagulations available on the market, and each type has its own drawbacks and benefits. When choosing a type, one should look at the tests they will be performing and the protocol. Some will require a specific type of tube, while others will be fine with any kind of tube. Routine hematology tests typically require a blood collection tube or syringe filled with EDTA, a chelating anticoagulant that prevents clot formation in the blood. However, EDTA is also susceptible to contamination, causing false negatives or questionable results. Fortunately, this is avoidable by following the "order of draw."
A study published in Clinical Chemistry and Laboratory Medicine examined the effects of material of blood collection tube on 22 assays of coagulation performed in clinical laboratories. The researchers used paired blood samples drawn into Blood Coagulation Tubes Vacutainer glass and plastic tubes to compare the results of coagulation tests using the two tubes. The researchers found that BD Vacutainer glass and plastic citrate tubes were equally effective in preventing clot formation. The only significant difference between the tubes was that BD Vacutainer glass tubes were more likely to contain EDTA than BD Vacutainer plastic tubes When using sodium citrate blood collection tubes, it is important to properly mix the specimen before storing. Ideally, the sample should be mixed with a rolling wrist motion and inverted 4 to 10 times. This will ensure that the clotting cascade is blocked and that the sample remains stable for up to 24 hours. These tubes are primarily used for blood samples submitted to diagnostic laboratories and are commonly used in blood group testing, however, can be useful for some hematology and molecular biology tests. They are filled with a solution of citrate that acts as an anticoagulant by chelating calcium, an essential component in the blood clotting process. Blood coagulation tubes made of plastic are increasingly being used in clinical laboratories to replace glass tubes. They are gaining popularity as they are inexpensive and can be stored indefinitely without deteriorating. They are not as effective as glass tubes, however, they do prevent clot formation and remain stable for up to 24 hours. Because the clotting cascade is prevented, it is not as sensitive to preanalytic factors and will give accurate test results. In November 2021, Q-Sera Pty. Ltd. and Terumo Corporation, a leading medical device company in Japan, announced partnership for manufacturing and use of the RAPClot, a rapid serum tube technology of Q-Sera in Japan.
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November 2023
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