In recent years, a revolutionary form of immunotherapy has emerged as a game-changer in the field of cancer treatment. CAR T cell therapy, or chimeric antigen receptor T cell therapy, has captured the attention of researchers, clinicians, and patients alike, offering hope where there was once despair. This groundbreaking treatment has gained recognition for its remarkable success in treating certain types of cancer, transforming the landscape of oncology and taking the medical world by storm.
CAR T Cell Therapy is a form of adoptive cell transfer that harnesses the power of a patient's immune system to fight cancer. It involves genetically modifying a patient's own T cells, a type of white blood cell responsible for immune response, to express chimeric antigen receptors (CARs) on their surface. These CARs are designed to recognize specific proteins or antigens present on cancer cells, enabling the engineered T cells to target and destroy cancerous cells with precision. The journey of a patient undergoing CAR T cell therapy begins with the collection of their T cells through a process called leukapheresis. The collected T cells are then transported to a specialized laboratory where they are genetically modified to express CARs. This process involves introducing a viral vector carrying the CAR gene into the T cells, which integrates into their genome and enables the production of CARs. Once the T cells have been successfully engineered, they are expanded in the laboratory to reach the desired therapeutic dose before being infused back into the patient. One of the most striking aspects of CAR T cell therapy is its remarkable efficacy, particularly in the treatment of certain hematological malignancies. In clinical trials, CAR T cell has demonstrated unprecedented response rates, with complete remissions seen in patients who had exhausted all other treatment options. For instance, in patients with relapsed or refractory acute lymphoblastic leukemia (ALL), CAR T cell has shown remarkable success, leading to long-term remissions in a significant proportion of patients.
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November 2023
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