Hepatocellular carcinoma is caused by many factors, including hepatitis B or C virus infection, nonalcoholic fatty liver disease, exposure to fungal aflatoxins, tobacco use, and sporadically genetic diseases. Treatment options for this cancer are limited, and drug resistance is a major problem. Anti-angiogenesis drugs are a type of cancer treatment that stop the growth of new blood vessels in tumors. This prevents the cancer from growing larger and spreading throughout the body.
Several types of anti-angiogenic agents are used in cancer therapy. Hepatocellular Carcinoma Drugs include monoclonal antibodies that specifically bind to VEGF or its receptor and block its signaling. Others are tyrosine kinase inhibitors that target one or more pro-angiogenic receptors. They can be effective in preventing the growth of blood vessels and can be used alone or in combination with other cancer therapies. Chemoembolization is a minimally invasive procedure that delivers and traps chemotherapy directly in the tumor, depriving the tumor of blood flow. This keeps the tumor from growing and is usually used as a palliative treatment. In this procedure, an interventional radiologist uses real-time X-ray imaging to guide a small catheter into the groin and the blood vessels supplying the liver tumor. Then, the radiologist injects a mixture of drugs through the catheter into the liver tumor. The combination of these drugs and the embolization stop the tumor’s blood supply from flowing to the cancer cells in the liver. This slows or stops the growth of the liver tumor and in about 2/3 of cases, causes it to shrink. After the chemoembolization, pain, nausea and fever may last a few hours to a week or more and are easily treated by medication. There might be fatigue and loss of appetite for a couple weeks or more, as well as some hair loss. Chemotherapy destroys cancer cells so that they can’t grow back. It also can help control the spread of cancer or ease symptoms. Doctors can send chemotherapy drugs directly into a vein or through a tube called a catheter. A port or pump might also be present that allows in receiving more of the Hepatocellular Carcinoma Drugs without it going through a needle. The Hepatocellular Carcinoma Drugs need to be taken at regular intervals and a record of what was taken must be maintained. It is important to inform the doctor in case of any side effects that don’t go away. The effects of chemotherapy vary from person to person. They can be mild to severe, depending on the type and number of drugs used. Before starting a new cycle of chemo, a doctor will check the blood count and other health conditions. If they find that the liver is too damaged to handle the drugs, then they may need to wait until it recovers. Surgery is a medical procedure in which a doctor cuts open parts of the body to remove, repair, or replace diseased or damaged tissue. Surgery can be used to treat many conditions, including cancers and infections. Hepatocellular Carcinoma Drugs is a common liver cancer that can occur in people with hepatitis B virus infection or cirrhosis of the liver. It is also very rare in children, usually occurring in people under 5. Despite efforts to increase screening, HCC remains a leading cause of cancer death worldwide. Treatment depends on tumor size, clinical performance, and liver function tests. Chemotherapy drugs may be used to kill cancer cells in the liver. These drugs may be given by mouth or injected into a blood vessel. Injections of chemotherapy drugs into the hepatic artery or vein deliver a large amount of the drug directly to the cancer cells in the liver.
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November 2023
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